Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl). Monoisotopic Mass: 1209.43±1.0. Leuprolide acts as an agonist at pituitary GnRH receptors. Souble in water or 1% acetic acid at a concentration of≥1mg/ml to give a clear, colorless solution. The key to the normal function of this hormone is the fact that it is released in pulses. But when used as a drug for long periods of time, the levels of this artificial hormone become consistently high.
By interrupting the normal pulsatile stimulation and the desensitization of the GnRH receptors; Storage 2℃ --8℃ ; it indirectly down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. This hormone when present in the body stimulates the production of sex steroids by the reproductive organs, the ovary and the testes. However, used on children or adolescents it could cause disastrous and irreversible damage to sexual functioning, and there is no scientifically valid or reliable research to show its effectiveness in treating autism.
Lucrin (Leuprorelin) is a drug that mimics the action of a hormone called gonadotrophin releasing hormone. This has the effect of causing reduced production of hormones by the reproductive organs, and it is this effect that is believed to cause a reduction in tumour growth in people with advanced prostate cancer. Lucrin is given via an injection into the fatty tissue under the skin (subcutaneous). The doctor will change the site of injection regularly.
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