Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone. The chemical name is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-Nethyl-L-prolinamide acetate (salt).
[Molecular Formula] C59H84N16O12. Current standard options for adjuvant treatment of premenopausal women include chemotherapy, antiestrogen therapy predominantly with tamoxifen, ovarian ablation by surgical oophorectomy or radiotherapy, and ovarian suppression by monthly luteinizing hormone–releasing hormone (LHRH) agonists.
[CAS No.] 53714-56-0 Leuprorelin acetate has proved to be an efficacious treatment for prostate cancer for many years. Specific Optical Rotation D(c=1,1%HAc): -38.0~-42.0°
Water Content(Karl Fischer): ≤5.0%. An accurate and user-friendly delivery system can only be a positive step forward, particularly as administration is more efficient and therefore saves time.
Acetate Content(by HPLC): ≤12.0%. This can result in a better standard of care for patients as more time is spent providing much needed support and advice.
Appearance: White powder.
Amino Acid Composition: ±10% of theoretical
Purity (by HPLC): ≥98.0%
Single Impurity(by HPLC): ≤1.0%
Peptide Content(by N%): ≥80%
Assay(By Anhydrous, Acetic Acid-free ): 97.0~103.0%
Bacterial Endotoxins: ≤5EU/mg
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