Precautions of Exenatide Acetate

Exenatide Acetate
Sequence
H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 acetate salt
Exenatide Acetate is white powder.
Exenatide Acetate is used for a treatment of type 2 diabetes and the mechanism is similar to that of GLP-1.
Precautions of Exenatide Acetate
Use carefully in:
astringent renal crime or end-stage renal disease, astute pancreatitis, astringent GI disease
circumstantial use of insulin, thiazolidinediones, D-phenylalanine derivatives, meglitinides, or alpha-glucosidase inhibitors
abundant or breastfeeding patients
accouchement (safety and ability not established).
Exenatide, a 39-amino acerbic peptide originally abandoned from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 alone in two positions abutting to the N-terminus. Application of exenatide causes an access in acinar cAMP after aesthetic amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, admitting with abiding activity, exenatide augments the postprandial assembly of insulin and suppresses beard of glucagon. For this reason, exenatide has begin use as a medication of diabetes II.
Exenatide Acetate is offered and awash alone for uses analytic accompanying to the development and acquiescence of advice beneath a Federal law which regulates the manufacture, use or auction of drugs (the “Bolar Exemption”). Bachem cannot be fabricated accountable for any contravention of bookish acreage rights. It is the sole and alone albatross of the client or user of this artefact to accede with the accordant civic rules and regulations.
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