Gonadorelin Acetate' other commonly used names are luteinizing hormone–releasing hormone (LHRH), luteinizing hormone–releasing factor dihydrochloride (for gonadorelin hydrochloride), luteinizing hormone–releasing factor diacetate tetrahydrate (for gonadorelin acetate), and luteinizing hormone–/follicle-stimulating hormone–releasing hormone (LH/FSH–RH).
For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s). Recently, several reports of adverse reactions after pulsatile GnRH (gonadorelin hydrochloride) infusion therapy have appeared in the medical literature. Although the cause of these reactions has been associated with GnRH itself, the contributions of impurities and degradation products in the administered drug have not been determined, suggesting that the use of high-purity material may be advantageous in controlling unwanted side effects. Appearance: White powder
The gonadorelin acetate drug substance was found to be stable for at least 12 months when stored at 24 degrees C in 50% relative humidity, and showed no degradation even under accelerated storage conditions. Similarly, the lyophilized product also showed excellent stability for at least 18 months when stored at 24 degrees C in 50% relative humidity. Water Content(Karl Fischer) :≤8.0%; Acetate Content(by HPLC): ≤10.0%.
Molecular Formula C55H75N17O13.C2H4O2; Molecular Weight 1242.34; CAS Registry Number 34973-08-5.
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