Tetracosactide Acetate is a synthetic analogue of the naturally-occurring adrenocorticotrophic hormone (ACTH). In the normal situation, ACTH is released from the pituitary gland at the base of the brain. It acts on the adrenal glands to stimulate the production of steroid hormones (glucocorticoids). If the adrenal glands are healthy, a single injection of tetracosactide results in a rise in blood cortisol (hydrocortisone) concentrations in 30 minutes.
Properties:
1 Appearance White to off-White powder Conforms
2 Solubility Soluble in water or acetic acid to give a clear, colorless solution
3 Identity by HPLC The retention is the same with the reference substance.
4 Specific Optical Rotation -99.0～-109.0(c=1,1%HAc) -102.6°
5 Amino Acid Composition ± 10% of theoretical
6 Water Content (Karl Fischer) ≤8.0% 3.8%
7 Acetate Content (By HPLC) ≤13.0% 11.5%
8 Related Substance (By HPLC) Total Impurities (%)≤2.0% Largest Single Impurity (%)≤ 1.0% 1.3% 0.8%
9 Assay(ByAnhydrous,AceticAcid-Free) 97.0～103.0% 98.2%
10 Bacterial Endotoxins ≤ 50 IU/mg
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