Thursday, December 29, 2011

What is Histrelin Acetate for

Histrelin is a man-made version of a hormone that is similar to the one normally released from the hypothalamus gland in the brain. Histrelin stimulates these cells to release luteinizing hormone and follicle-stimulating hormone. Thus it is considered a gonadotropin-releasing hormone agonist or GnRH agonist.
In study 2, suppression of LH was induced in all treatment naïve subjects and maintained in all pretreated subjects one month after implantation and continued through month 12. It works in the brain to reduce the blood levels of sex hormones, such as testosterone and estrogen. The histrelin implant is placed under the skin. In both trials the endpoints were achieved. The implant releases small amounts of histrelin in the body every day for 12 months.
Histrelin is used to treat advanced prostate cancer in adults. It will reduce the level of testosterone, a male hormone, in the blood. The sterile Vantas implantation device (provided with the implant) is used to insert the implant subcutaneously in the inner aspect of the upper arm. After 12 months, the implant must be removed.
Testosterone makes most prostate cancers grow. Histrelin is not a cure for prostate cancer, but it may help relieve the symptoms. After 12 months, the implant must be removed. At the time the implant is removed, another implant may be inserted to continue therapy.
Histrelin (Supprelin® LA) is used to treat central precocious puberty (CPP) in children. CPP is a condition where puberty begins at an unusually early age. After a transient increase, continuous administration of histrelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Wednesday, December 28, 2011

The Function of CRF (human, rat) Acetate

CRF (human, rat) Acetate stimulates adrenocorticotropic hormone (ACTH)secretory cells in adenohypohhysis to make it secrete ACTH.
It inhibits food intake in mammals. CRF plays a potent role in decreasing food intake in avian species. the efficacy of CRF, urocortin and urotensin I was directly compared using one dose, 0.1 µg.
Appearance: white powder
A conditional random field (CRF) is a statistical molding process often implemented in figure identification. Many specifically it is a type of judicial aimless probabilistic graphical framework. Them comprises expended to code experienced kinships 'tween ceremonials and conception uniform interpretations. Them comprises often used for labeling or parsing of successive data, such as natural language text or biological sequences and in computer vision.
Usage: Used for the treatment of adrenal insufficiency and for the emergency treatment of shock.
The results indicated that the suppressive effect on food intake was strongest for CRF followed by urotensin I, then urocortin. These results suggest that the structure of receptors for the CRF family in chicks may be somewhat different than in mammals.

CRF (human, rat) Acetate

CRF (human, rat) Acetate stimulates adrenocorticotropic hormone (ACTH)secretory cells in adenohypohhysis to make it secrete ACTH.
It inhibits food intake in mammals. CRF plays a potent role in decreasing food intake in avian species. the efficacy of CRF, urocortin and urotensin I was directly compared using one dose, 0.1 µg. The results indicated that the suppressive effect on food intake was strongest for CRF followed by urotensin I, then urocortin. These results suggest that the structure of receptors for the CRF family in chicks may be somewhat different than in mammals.
Appearance: white powder
Usage: Used for the treatment of adrenal insufficiency and for the emergency treatment of shock.

Monday, December 26, 2011

GRF(human)Acetate is an Effective Hypothalamic Hormone

GRF is a hypothalamic hormone which regulates the synthesis and secernment of somatotrophin from the front tooth pituitary. It is a 44-amino back breaker peptide endocrine brought forth in the arcuate nucleus of the hypothalamus. It is a white powder.

Molecular Formula C215H358N72O66S; Molecular Weight 5039.76; Purity (HPLC) 98.0%min. Diagnosis of growth hormone deficiency - not yet approved applications.

Single Impurity (HPLC) 1.0%max. Anterior pituitaries from the dwarf computer mouse breed "minuscule" behaved not release somatotrophic hormone or accumulate adenosine 3’,5-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing divisor (GRF). Dibutyryl bicyclic AMP, as well as the adenylate cyclase stimulators forskolin and cholera toxin, markedly caused growth hormone (GH) release.

Read more>> http://www.polypeptides.net/

Argireline Acetate and Acetyl Hexapeptide-3

Argireline Acetate(Acetyl Hexapeptide-3) is the trade name for Acetyl Hexapeptide-3, a synthetic anti-aging cosmetic ingredient derived from ALL natural proteins. It is a peptide, a chain made up of amino acids. Molecular Formula: C46H56N12O6.
Argireline has been shown to produce an anti-aging effect. within the skin.
Argireline is the trade diagnose for Acetyl Hexapeptide-3, a artificial anti-aging aesthetic factor derived from natural proteins. It follows a peptide, a mountain chain caused upwardly of amino acids. Argireline Acetate has been pictured successful research disciplines to help oneself lessening the apparent effectuates of maturing by portion coming down the deep furrows and bloods that occur close to the forehead and middles. As a result, a declamatory amount of cosmetics companionships include Argireline inwards the expression of their anti-aging merchandises. Molecular Weight: 888. 99.
More information: CAS of Argireline Acetate. As a result, a large number of cosmetics companies include Argireline in the formulation of their anti-aging products. These can include Creams, Lotions and Serums. etc.
Argireline is the trademark name of the mote acetyl radical hexapeptide-3. Argireline costs fabricated from the Spanish company Lipotec and comprises nonpareil by the live new components in anti aging skin care products.
In theory, repetitive muscle movements create lines and wrinkles and it is believed the attenuation of muscular contractions can reduce the depth of existing wrinkles and prevent the formation of new lines.

Sunday, December 25, 2011

Leuprorelin Acetate Leuprolide Acetate

Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl). Monoisotopic Mass: 1209.43±1.0. Leuprolide acts as an agonist at pituitary GnRH receptors. Souble in water or 1% acetic acid at a concentration of1mg/ml to give a clear, colorless solution. The key to the normal function of this hormone is the fact that it is released in pulses. The doctor will change the site of injection regularly. But when used as a drug for long periods of time, the levels of this artificial hormone become consistently high. This hormone when present in the body stimulates the production of sex steroids by the reproductive organs, the ovary and the testes.    
Lucrin (Leuprorelin) is a drug that mimics the action of a hormone called gonadotrophin releasing hormone. This has the effect of causing reduced production of hormones by the reproductive organs, and it is this effect that is believed to cause a reduction in tumour growth in people with advanced prostate cancer. Lucrin is given via an injection into the fatty tissue under the skin (subcutaneous).
By interrupting the normal pulsatile stimulation and the desensitization of the GnRH receptors; Storage 2--8; it indirectly down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. However, used on children or adolescents it could cause disastrous and irreversible damage to sexual functioning, and there is no scientifically valid or reliable research to show its effectiveness in treating autism.

Wednesday, December 21, 2011

Leuprorelin Acetate Suppliers

Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl). Monoisotopic Mass: 1209.43±1.0. Leuprolide acts as an agonist at pituitary GnRH receptors. Souble in water or 1% acetic acid at a concentration of1mg/ml to give a clear, colorless solution. The key to the normal function of this hormone is the fact that it is released in pulses. The doctor will change the site of injection regularly. But when used as a drug for long periods of time, the levels of this artificial hormone become consistently high. This hormone when present in the body stimulates the production of sex steroids by the reproductive organs, the ovary and the testes.    

Lucrin (Leuprorelin) is a drug that mimics the action of a hormone called gonadotrophin releasing hormone. This has the effect of causing reduced production of hormones by the reproductive organs, and it is this effect that is believed to cause a reduction in tumour growth in people with advanced prostate cancer. Lucrin is given via an injection into the fatty tissue under the skin (subcutaneous).

By interrupting the normal pulsatile stimulation and the desensitization of the GnRH receptors; Storage 2--8; it indirectly down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. However, used on children or adolescents it could cause disastrous and irreversible damage to sexual functioning, and there is no scientifically valid or reliable research to show its effectiveness in treating autism.

Read more>>  www.polypeptides.net

Tuesday, December 20, 2011

What is Elcatonin Acetate

Elcatonin Acetate is a calcitonin derivative used as an anti-parathyroid agent. Water Content(Karl Fischer) : 10.0%. Elcatonin injection prevented increases in urinary CTX and reduction of the BMDs in mice. In the noninjured femoral metaphysis, osteoclast surface increased until day 28, whereas elcatonin suppressed it. Appearance: White powder. In the fracture site, elcatonin facilitated osteoblast proliferation and did not delay the healing of the bone defect. Bone injuries accelerated bone turnover systemically and locally, and the elcatonin injections suppressed the systemic acceleration of bone resorption without a delay of filling regenerated cortical bone in the bone defect.
Elcatonin is a calcitonin derivative used as an anti-parathyroid agent. Most of the approximately 5 billion kilograms of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers.
Molecular Weight: 3363.82. In addition, it inhibits the bone salts dissolving and transferring and promotes the excretion of calcium and phosphorus in urine. Meanwhile, it inhibits renal tubules reabsorbing calcium, phosphorus and sodium and keeps blood calcium at normal level. It is mainly used for remitting or eliminating the pain caused by Osteoporosis.
Elcatonin Acetate is a Calcitonin derivative which is transformed from eel's calcitonin by changing the S-S bond into the stable C-N bond. An acetate (pronounced /ˈæsɪteɪt/) is a derivative of acetic acid. This term includes salts and esters, as well as the anion found in solution.It inhibits the absorption and autolysis of bones, thus leads to blood calcium descending.
In nature, acetate is the most common building block for biosynthesis. For example, the fatty acids are produced by connecting C2 units derived from acetate.

Monday, December 19, 2011

Sermorelin Acetate for Sale

[Products Name]     Sermorelin Acetate
[Molecular Formula]       C149H246N44O42
[CAS No.]      86168-78-7
[Product Description]
Appearance :White powder
Specific Optical Rotation(c=0.5,1%HAc) :-80.0~-90.0°
Water Content(Karl Fischer) :6.0%
Acetate Content(by HPLC) :15.0%
Amino Acid Composition :±10% of theoretical
Purity(by HPLC) :98.0%
Single Impurity(by HPLC) :1.0%
Peptide Content(by %N ) :80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :5EU/mg
More about:
Read more>> http://www.polypeptides.net/

Sunday, December 18, 2011

What is Gonadorelin Acetate

Gonadorelin Acetate is a white powder
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Available registration documents (CTD format): EU and US DMF. Both the purity and potency of the drug substance, the lyophilized product for injection, and the reconstituted material that would be transferred to the infusion pump system were monitored using high-performance liquid chromatography. [CAS No.] 71447-49-9.
Please note that regional minor differences in analytical procedures and acceptance criteria might occur. [Molecular Formula] C55H75N17O13. Although the cause of these reactions has been associated with GnRH itself, the contributions of impurities and degradation products in the administered drug have not been determined, suggesting that the use of high-purity material may be advantageous in controlling unwanted side effects. Specific Optical Rotation [a]eq \o(\s\up 6   
 (20),\s\do 2( D))20 D(c=1,1% HAc) : -55.0~-65.0°
Water Content(Karl Fischer) :8.0%
Acetate Content(by HPLC) :10.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :98.0%
Single Impurity(by HPLC) :1.0%
Peptide Content(by %N) :80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Becterial Endotoxins :5EU/mg
Soluble in water at a concentration of 10 mg/mL to give a clear solution not more intensely colored than reference solution Y5. For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).

How to Buy Leuprorelin Acetate

Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone. The chemical name is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-Nethyl-L-prolinamide acetate (salt).
[Molecular Formula] C59H84N16O12. Current standard options for adjuvant treatment of premenopausal women include chemotherapy, antiestrogen therapy predominantly with tamoxifen, ovarian ablation by surgical oophorectomy or radiotherapy, and ovarian suppression by monthly luteinizing hormone–releasing hormone (LHRH) agonists.
[CAS No.] 53714-56-0 Leuprorelin acetate has proved to be an efficacious treatment for prostate cancer for many years. Specific Optical Rotation D(c=1,1%HAc): -38.0~-42.0°
Water Content(Karl Fischer): 5.0%. An accurate and user-friendly delivery system can only be a positive step forward, particularly as administration is more efficient and therefore saves time.
Acetate Content(by HPLC): 12.0%.  This can result in a better standard of care for patients as more time is spent providing much needed support and advice.
Appearance: White powder.
Amino Acid Composition: ±10% of theoretical
Purity (by HPLC): 98.0%
Single Impurity(by HPLC): 1.0%
Peptide Content(by N%): 80%
Assay(By Anhydrous, Acetic Acid-free ): 97.0~103.0%
Bacterial Endotoxins: 5EU/mg

How to Buy Leuprorelin Acetate

Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone. The chemical name is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-Nethyl-L-prolinamide acetate (salt).
[Molecular Formula] C59H84N16O12. Current standard options for adjuvant treatment of premenopausal women include chemotherapy, antiestrogen therapy predominantly with tamoxifen, ovarian ablation by surgical oophorectomy or radiotherapy, and ovarian suppression by monthly luteinizing hormone–releasing hormone (LHRH) agonists.
[CAS No.] 53714-56-0 Leuprorelin acetate has proved to be an efficacious treatment for prostate cancer for many years. Specific Optical Rotation D(c=1,1%HAc): -38.0~-42.0°
Water Content(Karl Fischer): 5.0%. An accurate and user-friendly delivery system can only be a positive step forward, particularly as administration is more efficient and therefore saves time.
Acetate Content(by HPLC): 12.0%.  This can result in a better standard of care for patients as more time is spent providing much needed support and advice.
Appearance: White powder.
Amino Acid Composition: ±10% of theoretical
Purity (by HPLC): 98.0%
Single Impurity(by HPLC): 1.0%
Peptide Content(by N%): 80%
Assay(By Anhydrous, Acetic Acid-free ): 97.0~103.0%
Bacterial Endotoxins: 5EU/mg

Thursday, December 15, 2011

Oxytocin Acetate for Sale

Oxytocin Acetate is the name used by pharmaceutical companies to refer to the powdered substance that is used to create oxytocin products designed for medical and consumer use. Appearance: White powder. If you are looking to buy oxytocin in bulk for a manufacturing operation, you might want to search Oxytocin Acetate. [CAS No.] 50-56-6. [Molecular Formula] C43H66N12O12S2. Also known as alpha-hypophamine (α–hypophamine), oxytocin has the distinction of being the very first polypeptide hormone to be sequenced and synthesized biochemically by Vincent du Vigneaud et al. in 1953.
Water Content(Karl Fischer) :5.0%
Amino Acid Composition :±10% of theoretical
Acetate Content(by HPLC) :6.0~10.0%
Purity (by HPLC) :98.0%
Single Impurity(by HPLC) :1.0%
Peptide Content(by %N) :80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~102.0%
Bacterial Endotoxins :5EU/mg
However, if you are looking for the highest quality oxytocin product for consumer use, manufactured and distributed in the United States, you are already at the right place. Oxytocin (sold as Pitocin, Syntocinon) is a mammalian hormone that acts primarily as a neurotransmitter in the brain. Oxytocin is best known for its roles in female reproduction: 1) it is released in large amounts after distension of the cervix and vagina during labor, and 2) after stimulation of the nipples, facilitating birth and breastfeeding.
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Wednesday, December 14, 2011

Hexarelin Acetate for Sale

Hexarelin Acetate. Although relatively new, Hexarelin is becoming a popular choice as a performance enhancement drug. Hexarelin is currently available from several research companies. [Molecular Formula] C47H58N12O6. In studies where Hexarelin was injected subcutaneously, Growth Hormone, measured through plasma concentrations, increased significantly and within thirty minutes of injection. GH levels decreased back to normal around four hours post injection (1). The GH increase, has been found to be effective up to 2mg/kg, any further increase in dose was found to be ineffective in causing a GH response (2). Hexarelin is a synthetic hexaptide which has GH-releasing properties. Hexarelin, administered subcutaneously produces a dose-dependent GH response from the Pituitary.
[CAS No.]  140703-51-1
[Sequence]   His-2-Me-D-Trp-Ala-Trp-D-Phe-Lys-NH2
[Product Description]
Purity (HPLC)      98%min.
Appearance       White powder
Single Impurity (HPLC)      1.0%max
Amino Acid Composition     ±10% of theoretical
Peptide Content (N%)     80.0%
Water Content (Karl Fischer)      5.0%
Acetate Content (HPIC)       10.0%
MS (ESI)      Consistent
Mass Balance    95.0~105.0%

Tuesday, December 13, 2011

What is Elcatonin Acetate

Elcatonin Acetate is a calcitonin derivative used as an anti-parathyroid agent. Water Content(Karl Fischer) : 10.0%. Elcatonin injection prevented increases in urinary CTX and reduction of the BMDs in mice. In the noninjured femoral metaphysis, osteoclast surface increased until day 28, whereas elcatonin suppressed it. Appearance: White powder. In the fracture site, elcatonin facilitated osteoblast proliferation and did not delay the healing of the bone defect. Bone injuries accelerated bone turnover systemically and locally, and the elcatonin injections suppressed the systemic acceleration of bone resorption without a delay of filling regenerated cortical bone in the bone defect.
Elcatonin is a calcitonin derivative used as an anti-parathyroid agent.
Elcatonin Acetate is a Calcitonin derivative which is transformed from eel's calcitonin by changing the S-S bond into the stable C-N bond. An acetate (pronounced /ˈæsɪteɪt/) is a derivative of acetic acid. This term includes salts and esters, as well as the anion found in solution.It inhibits the absorption and autolysis of bones, thus leads to blood calcium descending. Molecular Weight: 3363.82. In addition, it inhibits the bone salts dissolving and transferring and promotes the excretion of calcium and phosphorus in urine. Meanwhile, it inhibits renal tubules reabsorbing calcium, phosphorus and sodium and keeps blood calcium at normal level. It is mainly used for remitting or eliminating the pain caused by Osteoporosis.
Most of the approximately 5 billion kilograms of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers. In nature, acetate is the most common building block for biosynthesis. For example, the fatty acids are produced by connecting C2 units derived from acetate.

Monday, December 12, 2011

What is Sermorelin Acetate

Sermorelin acetate (sermorelin) is the acetate salt of an amidated synthetic 29- amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues. Acetate Content(by HPLC) :15.0%. The structural formula for sermorelin acetate is:
The free base of sermorelin has the empirical formula C 149 H 246 N 44 O 42 S and a molecular weight of 3,358 daltons. Specific Optical Rotation(c=0.5,1%HAc) :-80.0~-90.0°; ater Content(Karl Fischer) :6.0%. Molecular Formula: C149H246N44O42.

Sermorelin is a sterile, non-pyrogenic, lyophilized powder intended for subcutaneous injection after reconstitution with Sodium Chloride Injection, USP. The reconstituted solution has a pH of 5.0 to 5.5. For example, "square wave" or pharmacological presentation of the exogenous hormone cannot be avoided since it is administered as a bolus, subcutaneous injection. Appearance :White powder. [CAS No.]: 86168-78-7.
Amino Acid Composition :±10% of theoretical
Purity(by HPLC) :98.0%
Single Impurity(by HPLC) :1.0%
Peptide Content(by %N ) :80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :5EU/mg

Friday, December 9, 2011

What is Leuprorelin Acetate

Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl). Monoisotopic Mass: 1209.43±1.0. Leuprolide acts as an agonist at pituitary GnRH receptors. Souble in water or 1% acetic acid at a concentration of1mg/ml to give a clear, colorless solution. The key to the normal function of this hormone is the fact that it is released in pulses. But when used as a drug for long periods of time, the levels of this artificial hormone become consistently high. 
By interrupting the normal pulsatile stimulation and the desensitization of the GnRH receptors; Storage 2--8; it indirectly down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. This hormone when present in the body stimulates the production of sex steroids by the reproductive organs, the ovary and the testes. However, used on children or adolescents it could cause disastrous and irreversible damage to sexual functioning, and there is no scientifically valid or reliable research to show its effectiveness in treating autism.
Lucrin (Leuprorelin) is a drug that mimics the action of a hormone called gonadotrophin releasing hormone. This has the effect of causing reduced production of hormones by the reproductive organs, and it is this effect that is believed to cause a reduction in tumour growth in people with advanced prostate cancer. Lucrin is given via an injection into the fatty tissue under the skin (subcutaneous). The doctor will change the site of injection regularly.
Read more>>  www.polypeptides.net

Wednesday, December 7, 2011

What is Argireline Acetate(Acetyl Hexapeptide-3)

Argireline Acetate is an acetate salt form of argireline which works by destabilizing what is called the SNAP receptor complex and decreases the visible signs of aging y reducing the deep wrinkles and lines that occur around the forehead and eyes. Peptides for personal use, peptide APIs, cosmetics peptides, custom peptide synthesis services,Amino acids and derivatives,other biological proteins , resin. It is a synthetic anti-aging cosmetic derived from natural proteins. In addition to this, it also slows or even stops the excessive release of catecholamine, which is known to help in wrinkle formation. Studies show that applying a small amount (about 5-10%) of the solution over a period of 20 to 25 days can show positive results with improved skin texture. Skin topography analysis of an oil/water (O/W) emulsion containing 10% of the hexapeptide on healthy women volunteers reduced wrinkle depth up to 30% upon 30 days treatment.
Packing: plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage: a cool(2~8 ℃) & dry place protected from light, keep package close when not in use.
[Product Description]
1.Appearance :White powder
2 .Water Content(Karl Fischer) :≤5.0%
3 .Acetate Content(by HPLC) :≤15.0%
4 .Amino Acid Composition :±10% of theoretical
5 .Purity (by HPLC) :≥95.0%
6 .Single Impurity(by HPLC) :≤2.0%
7 .Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
8 .Bacterial Endotoxins :≤10EU/mg
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How to Get Teriparatide Acetate

Teriparatide Acetate is a synthetic polypeptide that consists of the 1-34 amino-acid fragment of human parathyroid hormone, the biologically active N-terminal region.  Teriparatide is a recombinant form of parathyroid hormone. CAS No. 52232-67-4(net) Molecular Formula C181H291N55O51S2 Molecular Weight 4117.72.
Teriparatide (Forteo) is a recombinant form of parathyroid hormone, used in the treatment of some forms of osteoporosis. Teriparatide Acetate affects calcium and phosphorus metabolism in a pattern consistent with the known actions of endogenous PTH (i.e., increases serum calcium and decreases serum phosphorous.) Teriparatide Acetate binds to the same receptors as PTH and is known to exert effects identical to that of PTH on the bone and the kidney. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Parathyroid hormone is secreted by the four parathyroid glands found on or embedded in the two lateral lobes of the thyroid gland. hPTH 1-34 acts on bone to mobilize calcium and on the kidney to reduce calcium clearance, increase phosphate excretion, stimulate the release of cyclic AMP in the urine, and stimulate the conversion of 25-hydroxyvitamin D3(25-OH-D3) to the active form 1, 25-dihydroxyvitamin D3(1,25(OH)2D3).
Teriparatide Acetate is used for the treatment of osteoporosis in men and postmenopausal women and is effective at reducing the incidence of new vertebral and nonvertebral fragility fractures in osteoporotic patients. Unlike other treatments for osteoporosis that primarily reduce bone turnover, Teriparatide Acetate reduces bone turnover, stimulates the formation of new bone, and increases bone mass. Teriparatide Acetate may be an acceptable alternative for the treatment of osteoporosis in patients who have failed other treatment modalities.
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Tuesday, December 6, 2011

How to Buy Tetracosactide Acetate

Tetracosactide Acetate is a synthetic analogue of the naturally-occurring adrenocorticotrophic hormone (ACTH). In the normal situation, ACTH is released from the pituitary gland at the base of the brain. It acts on the adrenal glands to stimulate the production of steroid hormones (glucocorticoids). If the adrenal glands are healthy, a single injection of tetracosactide results in a rise in blood cortisol (hydrocortisone) concentrations in 30 minutes.
Properties:
1 Appearance  White to off-White powder  Conforms
2 Solubility  Soluble in water or acetic acid to give a clear, colorless solution
3 Identity by HPLC  The retention is the same with the reference substance.
4 Specific Optical Rotation  -99.0~-109.0(c=1,1%HAc)  -102.6°
5 Amino Acid Composition  ± 10% of theoretical
6 Water Content (Karl Fischer)  ≤8.0%  3.8%
7 Acetate Content (By HPLC)  ≤13.0%  11.5%
8 Related Substance (By HPLC) Total Impurities (%)≤2.0% Largest Single Impurity (%)≤ 1.0%  1.3% 0.8%
9 Assay(ByAnhydrous,AceticAcid-Free)  97.0~103.0%  98.2%
10 Bacterial Endotoxins  ≤ 50 IU/mg
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Sunday, December 4, 2011

What is Eptifibatide Acetate

Eptifibatide Acetate is a white to Off-white powder.
CAS NO 148031-34-9
purity  :98% min
1 APPearence White to Off-white powder Comforms
2 SPEcific Optical Rotation -75.0~-95.0( c=1%,HAc) -84.86°
3 Water Content(Karl Fischer) ≤8.0% 2.53%
4 Amino Acid Composition ±20% Conforms
5 Acetate Conten(By HPLC) ≤15.0% 2.2%
6 Peptide Purity(By HPLC) ≥98.0% by area integration 99.9%
7 Related Substance(By HPLC) Total Impurities(%)≤2.0% Largest Single
8 .Purity(by HPLC) :≥98.0%
9 .Single Impurity(by HPLC) :≤1.0%
10 .Peptide Content(by %N) :≥80%
11.Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
12.Bacterial Endotoxins :≤5EU/mg

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Friday, December 2, 2011

What is Vasopressin

Vasopressin is a relatively small (peptide) molecule that is released by the pituitary gland at the base of the brain after being made nearby (in the hypothalamus). The vasopressins are peptides consisting of nine amino acids (nonapeptides). The amino acid sequence of arginine vasopressin is Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly, with the cysteine residues forming a sulfur bridge. 
Vasopressin has an antidiuretic action that prevents the production of dilute urine (and so is antidiuretic). Vasopressin has been implicated in memory formation, including delayed reflexes, image, short- and long-term memory, though the mechanism remains unknown, and these findings are controversial.
Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. A syndrome of inappropriate secretion of vasopressin which results in the inability to put out dilute urine, perturbs fluid (and electrolyte) balance, and causes nausea, vomiting, muscle cramps, confusion and convulsions may occur in association with oat-cell lung cancer, pancreatic cancer, prostate cancer, and Hodgkin's disease as well as a number of other disorders.  It is thought that vasopressin, released into the brain during sexual activity, initiates and sustains patterns of activity that support the pair-bond between the sexual partners; in particular, vasopressin seems to induce the male to become aggressive towards other males.
Vasopressin has a vasopressor action and so can stimulate contraction of arteries and capillaries. Hence the name "vasopressin." Vasopressin is also known as antidiuretic hormone (ADH). One of the most important roles of AVP is to regulate the body's retention of water; it is released when the body is dehydrated and causes the kidneys to conserve water, thus concentrating the urine, and reducing urine volume.

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Thursday, December 1, 2011

What is Gonadorelin Acetate

Gonadorelin Acetate' other commonly used names are luteinizing hormone–releasing hormone (LHRH), luteinizing hormone–releasing factor dihydrochloride (for gonadorelin hydrochloride), luteinizing hormone–releasing factor diacetate tetrahydrate (for gonadorelin acetate), and luteinizing hormone–/follicle-stimulating hormone–releasing hormone (LH/FSH–RH).
For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s). Recently, several reports of adverse reactions after pulsatile GnRH (gonadorelin hydrochloride) infusion therapy have appeared in the medical literature. Although the cause of these reactions has been associated with GnRH itself, the contributions of impurities and degradation products in the administered drug have not been determined, suggesting that the use of high-purity material may be advantageous in controlling unwanted side effects. Appearance: White powder
The gonadorelin acetate drug substance was found to be stable for at least 12 months when stored at 24 degrees C in 50% relative humidity, and showed no degradation even under accelerated storage conditions. Similarly, the lyophilized product also showed excellent stability for at least 18 months when stored at 24 degrees C in 50% relative humidity. Water Content(Karl Fischer) :≤8.0%; Acetate Content(by HPLC): ≤10.0%.
Molecular Formula C55H75N17O13.C2H4O2; Molecular Weight 1242.34; CAS Registry Number 34973-08-5.
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