What is Atriopeptin II?

Sequence
Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg
Biochem/physiol Actions
Activates particulate guanylyl cyclase, cardiac atrial peptide which relaxes both intestinal and vascular smooth muscle.
Atrial natriuretic peptide (ANP), atrial natriuretic agency (ANF), atrial natriuretic hormone (ANH), or atriopeptin, is a able vasodilator, and a protein (polypeptide) hormone buried by affection beef cells. It is complex in the homeostatic ascendancy of physique water, sodium, potassium and fat (adipose tissue). It is appear by beef beef in the top accommodation (atria) of the affection (atrial myocytes) in acknowledgment to top claret pressure. ANP acts to abate the water, sodium and adipose endless on the circulatory system, thereby abbreviation claret pressure.
Atriopeptin is a 28-amino acerbic peptide with a 17-amino acerbic ring in the average of the molecule. The ring is formed by a disulfide band amid two cysteine residues at positions 7 and 23. ANP is carefully accompanying to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which all allotment the aforementioned amino acerbic ring. ANP was apparent in 1981 by a aggregation in Kingston, Ontario, Canada afterwards they fabricated the seminal ascertainment that bang of atrial (but not ventricular) tissue extracts into rats acquired copious natriuresis.
Physiological effects
ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist bounden causes a abridgement in claret aggregate and accordingly a abridgement in cardiac achievement and systemic claret pressure. Lipolysis is added and renal sodium reabsorption is decreased. The all-embracing aftereffect of ANP on the physique is to adverse increases in claret burden and aggregate acquired by the renin-angiotensin system.
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