Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. When present in the bloodstream, it acts on particular cells of the pituitary gland called gonadotropes. Histrelin stimulates these cubicles to discharge interstitial cell-stimulating hormone and follicle-stimulating internal secretion. Thus it is deliberated a gonadotropin-releasing hormone agonist or GnRH agonist.
Histrelin is marketed by Endo Pharmaceuticals under the brand name cites Vantas and Supprelin LA.
The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and its molecular weight is 1443.70 (or 1323.52 as free base). The chemical structure of the free base (histrelin) is represented below in Figure 1. It works in the brain to reduce the blood levels of sex hormones, such as testosterone and estrogen. The histrelin implant is placed under the skin. The implant releases small amounts of histrelin in the body every day for 12 months.
Histrelin (Vantas®) is used to treat came on prostate malignant neoplastic disease fashionable adults. It will bring down the level of testosterone, a male hormone, in the blood. Testosterone makes most prostate cancers grow. Histrelin is not a cure for prostate cancer, but it may help relieve the symptoms.
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