Pramlintide Acetate (Symlin), a medication for people with type 1 or type 2 diabetes, is an injected medication that can reduce a person’s insulin requirement. Synthetic analog of the naturally occurring neuroendocrine hormone amylin. Like lab-produced insulin, Symlin is an analogue of a naturally occurring hormone that is released by the beta cells of the pancreas and helps with blood glucose control. Possible side effects: nausea, most commonly, which may get better with time.
Amylin is colocated with insulin in pancreatic beta cells and is cosecreted with insulin in response to food intake. Amylin slows gastric emptying, suppresses glucagon secretion, and regulates food intake by centrally mediated modulation of appetite. D-mannitol as a tonicity modifier, and acetic acid and sodium acetate as pH modifiers. SYMLIN (pramlintide acetate injection) has a pH of approximately 4.0.
Pramlintide acetate is a white powder that has a molecular formula of C171H267N51O53S2· x C2H4O2 (3< x <8); the molecular weight is 3949.4. Pramlintide acetate is soluble in water.
Pramlintide is delivered as an acetate salt. By augmenting endogenous amylin, pramlintide aids in the absorption of glucose by slowing gastric emptying, promoting satiety via hypothalamic receptors (different receptors than for GLP-1), and inhibiting inappropriate secretion of glucagon, a catabolic hormone that opposes the effects of insulin and amylin.
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