CAS No. 86784-80-7
Sequence
Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn- Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
Corticotropin-releasing factor, CRF is a ancestors of accompanying neuropeptides in vertebrates. This ancestors includes corticotropin-releasing hormone, urotensin-I, urocortin and sauvagine. The ancestors can be aggregate into 2 abstracted paralogous lineages, with urotensin-I, urocortin and sauvagine in one accumulation and CRF basic the added group. Urocortin and sauvagine arise to represent orthologues of angle urotensin-I in mammals and amphibians, respectively. The peptides accept a array of physiological furnishings on accent and anxiety, vasoregulation, thermoregulation, advance and metabolism, alteration and reproduction in assorted species, and are all appear as prohormones.
Corticotropin-releasing hormone(CRH) is a hormone begin mainly in the paraventricular basis of the beastly hypothalamus that regulates the absolution of corticotropin (ACTH) from the pituitary gland. From here, CRF is transported to the antecedent pituitary, aesthetic adrenocorticotropic hormone (ACTH) absolution via CRF blazon 1 receptors, thereby activating the hypothalamic–pituitary–adrenal arbor (HPA) and appropriately glucocorticoid release.
CRH is evolutionary accompanying to a amount of added alive peptides. Urocortin acts in vitro to activate the beard of adrenocorticotropic hormone. Urotensin is begin in the teleost caudal neurosecretory arrangement and may play a role in osmoregulation and as a corticotropin-releasing factor. Urotensin-I is appear from the urophysis of fish, and produces ACTH and consecutive cortisol absolution in vivo. The nonhormonal allocation of the prohormone is anticipation to be the urotensin bounden protein (urophysin). Sauvagine (P01144), abandoned from frog skin, has a almighty hypotensive and diuretic effect.
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